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KMID : 0939920080400010011
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대한암학회지
2008 Volume.40 No. 1 p.11 ~ p.15
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A Phase II Study of Leucovorin, 5-FU and Docetaxel Combination Chemotherapy in Patients with Inoperable or Postoperative Relapsed Gastric Cancer
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Lee Kwang-Sun
Park Eun-Kyung
Lee Sang-Jae
Jang Joung-Soon
Lee Ha-Yeon
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Abstract
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Purpose: To estimate the effect and toxicity of bimonthly low-dose leucovorin (LV) and fluorouracil (5-FU) bolus plus continuous infusion(LV5FU2) with docetaxel combination chemotheraphy in patients with inoperable or postoperative relapsed gastric cancer.
Materials and Methods: Total 27 patients are enrolled in this study. LV 20 mg/m2 (bolus), 5FU 400 mg/m2 (bolus), 5-FU 600 mg/m2 (24-hour continuous infusion) on day 1, 2, 15, and 16, docetaxel 60 mg/m2 (1-hour infusion) on day 15 every 4 weeks.
Results: Total of 141 cycles were administered and response rate were 36.8% with 2 complete response (10.5%) and 5 partial response (26.3%) in 19 evaluable patients. The median response duration is 8.1 months(95% CI, 4.0∼12.1). The median progression-free survival time is 6.7 months (95% CI, 5.0∼8.5) and the median overall survival time is 11.9 months (95% CI, 4.8∼19.1). The grade 3-4 toxcity of neutropenia (24.8%) and anemia (11.3%), neutropenic fever (2.8%) is observed. The grade 1 toxcity of injection site reaction is observed all patients and the grade 1-2 toxcity of alopecia is observed 60%.
Conclusions: LV5FU2 with docetaxel combination chemotheraphy is effective and tolerable in patients with inoperable or postoperative relapsed gastric cancer. (Cancer Res Treat. 2008;40:11-15)
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KEYWORD
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Docetaxel, Fluorouracil, Stomach neoplasms
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